Sentence examples for be a real polymorphism from inspiring English sources
By incorporating into the cDNA library multiple individuals from populations spanning a large portion of the geographical range of D. serrata, we were able to identify 11,057 putative single nucleotide polymorphisms (SNPs), with 278 different contigs having at least one "double hit" SNP that is highly likely to be a real polymorphism.
In order to investigate, whether this sequence variation is a real polymorphism according to the Hardy-Weinberg equilibrium, a PCR-based RFLP (restriction fragment length polymorphism) analysis was established for a simple and inexpensive testing of larger cohorts of patients.
At the same time many polymorphisms were recorded for RASSF1A and in many cases it was not clear whether it was a real single nucleotide polymorphism or somatic mutation in cancer cells because control normal cells were not available [8].
In our study, plasma IL-6 values could be very helpful and convincing to reinforce the hypothesis that the observed effect of the IL-6 rs1800795 polymorphism is a real biological result.
To confirm that each germline variant detected by sequencing was a real mutation and not a polymorphism, 103 unrelated normal individuals (corresponding to 206 chromosomes), originating from the same geographical area and with no family history for breast cancer, were used as controls and screened for each gene variant identified.
All evidences point to the fact that the characterized amino acid exchange Cys 169Tyr is a real mutation and is not a polymorphism as described by Murgia et al. (connexin-deafness homepage).
Although a large proportion of these are likely to be real polymorphisms, in practice it is difficult to identify a priori without further testing which of these 3,219 SNPs are also spurious mutations introduced during reverse transcription, cDNA library construction and contig assembly.
That is a real motivation.
This is a real challenge.
