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This strategy for cancer control is based on the presumption that because cancer develops through a multi-step process, each step may be a prospective target for reversing or suppressing the process.
Therefore, Fus1 may have an important role in the regulation of cellular radiosensitivity/radioresistance in normal and tumor tissues as well as be a prospective target for therapies that better balance risks and benefits of radiation treatment of tumors.
Vilimas et al. [41] reported that overactivation of NF-κB in T-cell ALL may lead to malignant transformation of hematopoietic stem cells; thus, targeting NF-κB and inhibiting its activity could be a prospective target in T-cell ALL therapy.
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A number of studies have suggested that chemotherapeutic drugs can induce both apoptosis and autophagy, and autophagy is a prospective target for cancer therapy. 1, 2 However, these studies report conflicting roles of autophagy in drug-induced cancer cell death, with some studies concluding that it protects cells from apoptosis, and others reporting that it promotes cell death.
95 The estrogen-related receptor alpha receptor has been promulgated as a prospective target for breast cancer therapy based in part on preclinical analyses.
The maternally provided histone mRNAs are one likely candidate as a prospective target of NELF activity during oogenesis.
In the latter publication we show that the future therapeutic success of a prospective target can be predicted a-priori in large integrated datasets, based on the gene's expression behavior.
In this regard, Msi1 might be a positive regulator of tumor progression and a prospective target for therapeutic intervention.
A second is a prospective visual code of the corresponding target.
Juventus's Arturo Vidal, Milan's Nigel de Jong and Ajax's Daley Blind are all prospective targets as clubs enter the final week of the summer window.
This is a prospective study.
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