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The panel of three epidemiologists has judged there to be a "probable link" between exposure to PFOA and several health conditions: kidney and testicular cancers, pregnancy-induced hypertension, thyroid disease, ulcerative colitis, and high cholesterol.
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The C8 Science Panel is a three-person group set up under a 2004 legal settlement to determine whether there is a probable link between PFOA exposure and any human disease.
Heavily influenced by the study by Savitz et al. (2012), a recent review of existing literature concluded that there is a probable link between exposure to PFOA and pregnancy-induced hypertension/preeclampsia (C8 Science Panel 2011).
The settlement also established a Science Panel of public health scientists to assess whether or not there is a probable link between PFOA exposure and disease in the community.
The weight of evidence from the combination of studies within this population was heavily considered in the determination by the C8 Science Panel that there was a probable link between PFOA exposure and testicular and kidney cancers.
The results of analyses from this cohort have been used to support decisions by the C8 Science Panel regarding whether or not there is a probable link between PFOA exposure and human disease (C8 Science Panel 2012).
A pretrial settlement required DuPont to provide funding for an independent community health study called the C8 Health Project (C8 Health Project 2012; Frisbee et al. 2009), and also resulted in the creation of the C8 Science Panel (C8 Science Panel 2012), which was tasked with determining whether there was a probable link between PFOA and disease in the community living near the plant.
While we note the C8 panel finding that there is not a probable link between PFOA exposure and kidney disease [ 46], the unique vulnerability of children to PFAAs has not been studied longitudinally, let alone in the lower ranges of exposure in whom steeper dose-response relationships are noted.
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