Sentence examples for be a primary trigger from inspiring English sources

While the underlying pathophysiology of the disease remains unknown, there is mounting evidence that toxic protein misfolding and/or aggregation may be a primary trigger for motor neuron dysfunction and loss.

This, combined with the production of nitric oxide by host immune cells and the likely hypoxic nature of the granuloma, makes a strong, albeit circumstantial, case for this regulon to be a primary trigger in the metabolic shiftdown to achieve the non-replicative state.

As shown in Figure 1, recognition of the naked MSU crystal by Toll-like receptor (TLR 2 and TLR4, which are normally involved in triggering innate host defense responses to infectious pathogens, was recently discovered to be a primary trigger of the inflammatory and degenerative tissue reactions associated with gouty arthritis [ 4, 5].

Binding of Aβ to the plasma membrane is thought to be a critical step in development of Alzheimer's disease [3], and the formation of Aβ plaques is a primary trigger of neuron degeneration [4].

With the systems level approach employed in this study, we established a broader picture of the hierarchical organization and compositional complexity of upregulated transcriptional network supported by direct physiological evidence that oxidative signal caused by transient increases in intracellular H2O2 is a primary trigger for network activation.

Acknowledging that drinking a little wine may offer some anti-inflammatory benefits,drinking too much alcohol is a primary trigger for inflammation and liver damage.

Oligodendrocyte axonal interaction may be disturbed and constitute a primary trigger for axonal degeneration, oxidative stress and mitochondrial dysfunction in the axons of AMN patients.

Active caspase 3 seemed to accumulate in myelinated and demyelinated axons (axons with strong punctate MBP immunostaining pattern), suggesting that myelin is not a primary trigger for activation of the caspase pathway in axons.

Mechanical silencing is suggested to be a primary mechanism underlying CIM; that is, triggering the myosin loss, muscle wasting and myosin PTMs.

The Arabidopsis Hsf family is larger than that which has been described in any animal system [ 1], and at present, no single Hsf has been identified as a primary trigger of the heat shock response.

Dimerized vitamin A has been proposed as a primary trigger of retinal degeneration (Eldred, 1995).