The excessive production of reactive oxygen species damages the lung tissue and results in oxidative stress, which is a primary pathogenic process in COPD.
The present study was designed to investigate the possibility of mtDNA lesion accumulation in podocytes, which are a primary pathogenic site of FSGS, during the development of glomerulopathy in puromycin aminonucleoside nephrosis (PAN).
Brain stress, being a primary pathogenic basis of metabolic syndrome, conceivably can underlie the development of metabolic syndrome related CVDs.
It is still unknown whether MD in the brains of patients with SCZ is a primary pathogenic change or a secondarily induced process, and the aforementioned inconclusive findings create more questions than answers about the origin of SCZ.
Thus, release of these factors leads to increased levels in serum and cannot be considered a primary pathogenic event in vasculitis, whereas, for example, enhanced ET-1 levels in scleroderma and Raynaud's have pathogenic relevance.
To address whether thymic production of pathogenic autoimmune T cells could be a primary cause of ocular disease, we undertook studies in the genetically predisposed arthritic SKG mice.
Would it be a primary and direct one, promoting erroneously protein degradation, which results in pathogenic fragments?
In particular, the relevance of extracellular deposition of PrPSc in disease progression is controversial, being proposed to represent either a primary pathogenic event, an epiphenomenon of neuronal death or a cell defense reaction.
In both pathologies, mammalian target of rapamycin (mTOR) pathway activation has been demonstrated [ 3– 6], possibly representing a primary pathogenic mechanism and a potential target for new treatment approaches [ 7].
