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Our results demonstrate that mitochondrial dysfunction (of diverse etiology) can be a primary event in development in SA.
Moreover, eIF4E was also strongly upregulated in normal adipose tissue of FUS-DDIT3 transgenic mice, suggesting that overexpression of eIF4E may be a primary event in the initiation of liposarcomas.
It has been suggested that sub-sets of infiltrating T cells may even be a primary event in the initiation of adipose tissue inflammation and development of IR [1], [2], [3].
However, under certain circumstances, inflammation could be a primary event that leads to the neurodegenerative process.
Misincorporation of BMAA into proteins may therefore be a primary event resulting in fibril formation and neurodegeneration.
From all the observed cellular abnormalities in cystic epithelia, proliferation was considered to be a primary event in cyst initiation and growth.
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Inflammation is a primary event in atherogenesis.
The results suggest that the accumulation of C4S-, C0S-, and C6S-carrying PGs, and of BSP and OPN is a primary event at the initial PF attachment, and is involved in the adhesion of PFs and mineralization of the initial attachment layer.
This suggested that membrane disruption was a primary event rather than a consequence of swelling after failure of membrane ion pumps.
Whether this is a primary event that causes a decline in health with advancing age or a result of a general decrease in metabolism in the elderly remains a topic for further investigation.
Thus although it is unclear if the reduction of NK cells in our patients is a primary event increasing the susceptibility of disease or a secondary effect of viral infection, Ahlenstiel's study suggests that the former is possible.
More suggestions(15)
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