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These results suggest an interplay between mitochondrial dysfunction and epigenetic alterations, which may be a primary determinant of DOX-induced cardiotoxicity.
Our results suggest that the dietary FA content and composition may be a primary determinant of diastolic, but not systolic, dysfunction in animal models of diet-induced obesity.
The 13C-glucose labeled cultures therefore generate heavy labeled acetyl-coA at about four times the rate that D3-acetate labeled cultures generate acetyl-coA, which may be a primary determinant of why heavy acetylation incorporation via D3-acetate labeling is slower.
In the formulation of polymer microspheres (MSs) loaded with verapamil hydrochloride (VRP), a low molecular weight ionizable drug, by W/O/W emulsification, the pH of the external aqueous phase proved to be a primary determinant of both IE and drug release behavior.
Blood flow has long been hypothesized to be a primary determinant of arterial diameter growth.
We hypothesized that the characteristics defining eligibility for advanced HF therapies would be a primary determinant of outcomes in these patients.Ambulatory patients with advanced HF (New York Heart Association class III-IV, Interagency Registry for Mechanically Assisted Circulatory Support profiles 4-7) wenrolledlled across 11 centers from May 2013 to February 2015.
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Substantial effort has been dedicated to determining whether age is a primary determinant of ICU outcome for very old patients [ 6- 9, 11, 13- 15, 20, 29, 36- 39].
Spore core dehydration is a primary determinant of heat resistance.
After stroke preventive treatments are a primary determinant to avoid a recurrent cardiovascular event.
Cox, F., Barsoum, N., Lilleskov, E. A. & Bidartondo, M. I. Nitrogen availability is a primary determinant of conifer mycorrhizas across complex environmental gradients.
Excessive endogenous glucose production by gluconeogenesis is a primary determinant of hyperglycemia in patients with type 2 diabetes.
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