Break-induced replication is a preferred pathway of repairing DSBs that are one-sided and hence only one of the end shares homology with an intact DNA sequence (Fig. 1) [37].
Although our results show that macrophage infiltration of the brain parenchyma can occur by migrating of macrophages along the olfactory nerve, as previously shown in mouse models, at this stage it is not clear whether there is a preferred pathway (Kaminski et al., 2012; Smithson and Kawaja, 2010).
If NHEJ is less active in canine cells, then HR might be a preferred dsb repair pathway.
Our study suggested that although a variety of cellular processes could regulate fitness traits under selection, passing AP fitness costs to downstream genes, and thereby retaining variation in signaling pathways (such as the Ras/PKA pathway) seems to be a preferred approach used by adapting populations over the course of evolution (Kvitek and Sherlock 2013; Lorenz and Cohen 2014).
Delaware might be a preferred location.
Let β1 be a preferred basis of Λ1 and β2 a preferred basis of Λ2.
However, more recent interpretations suggest that glycolysis is a preferred metabolic pathway for highly proliferative cells, and the shift to a glycolytic phenotype is part of a larger adaptive metabolic program to support growth and proliferation [7] [9].
Particularly for those progenitor cells reside in hypoxic niches, glycolytic and anaerobic respiration is a preferred energetic pathway and CtBP could be the essential regulator to support their self-renewal and pH homeostasis.
No matter the G-quadruplex is in a free form or becomes completely bound by two K+ ions, the top gate area appeared larger than the bottom one, suggesting that the top gate is a preferred K+ binding pathway.
Currently, the intratympanic administration to achieve uptake via the round window is a preferred otological drug development pathway, as it obviates possible systemic side effects (unlikely to be a factor with ADAC, but of significant regulatory body concern), and this also counters metabolism/elimination.
