Since obesity is a predisposing condition for the cluster of cardiovascular and metabolic derangements collectively known as the metabolic syndrome, effective endocannabinoid-modulatory anti-obesity therapeutics would also help redress other major health problems including type-2 diabetes, atherothrombosis, inflammation, and immune disorders.
A pre-existing aseptic pericarditis is a predisposing condition in nearly half of cases [ 3].
If trachoma is a predisposing condition, ocular variola may be rare in Western industrialized nations if smallpox reappears.
Metabolic syndrome characterized by dyslipidemia, hyperglycemia, insulin resistance, hypertension, and obesity also is a predisposing condition for atherosclerosis and CHD [ 1].
The majority of gastric cancer cases are believed to be caused by chronic infection with the bacterium Helicobacter pylori, and atrophic corpus gastritis is a predisposing condition to gastric cancer development.
The FV gene's most studied polymorphism is the single point mutation c.1691G4A leading to a p.Arg506Gln amino acid change, which determines a resistance to aPCR (activated protein C), proved to be a stroke predisposing condition [13].
The aim of the present study was also to evaluate the usefulness of CD1a expression as a marker of evolution of the metaplastic lesions, as metaplasia has been regarded as a predisposing condition for the development of oesophageal Ca (Malhi-Chowla et al, 2000; Moreto, 2003).
Type A prostaglandins (PGA1 and 16,16-dimethyl-PGA2-methyl ester) were found to block the proliferation of HTLV-I infected cord blood lymphocytes (CBL) in vitro, thus preventing the clonal immortalisation that is considered as a predisposing condition to HTLV-I positive leukaemia.
5, 6, 12 The fact that no methylation was observed in any sites of the normal breast tissues of the patients with BRCA1-unmethylated tumors seems to suggest that BRCA1-methylated tumors are unlikely to develop without a predisposing condition; that is, the presence of BRCA1-methylated epithelial cells.
