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Spotting mutations in these genes could therefore be a predictive test for a disease that kills 44,000 American women each year.
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Molecular analysis represents, in these types of diseases, an essential tool to confirm the symptomatic manifestations, but it is also a predictive test.
Whether the proliferation signature can be converted into a predictive test should be evaluated in a large prospective trial in which other measures for proliferation should also be evaluated.
Taken together with other studies, we conclude that FGF21 is an indicator of liver function and stress, and has the potential to be a predictive biomarker for liver function test, early diagnosis of liver cancer, other hepatic diseases and minimally-invasive clinical analysis.
An exhaustive longitudinal study of AML patients having CR without transplant showed that WT1 transcript levels could be used as a predictive test, yet PB was far less sensitive than BM as a cell source for measurement.
All of these criteria are essential if a predictive test is to have practical utility in a clinical context.
The proliferation signature is a strong prognostic factor, with the potential to be converted into a predictive test.
It has been suggested that a substantial proportion of highly radiosensitive (HR) breast cancer patients may be A-T heterozygotes, and that screening for mutations in the A-T gene could be used as a predictive test.
It has a high prognostic value and unlike other signatures it has the potential to be converted into a predictive test.
Kazunari Yamada et al. reported that the volume of the liver receiving a dose in excess of 30 Gy, with conventional fractionation, could be used as a predictive test for damage in liver function [ 19].
This story, reported on the same day as Story 2, was based on a predictive test for Alzheimer disease that had been published in Nature Medicine[26].
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CEO of Professional Science Editing for Scientists @ prosciediting.com