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Nevertheless, their study showed that 6 weeks after initiation of treatment with anti-TNF drugs, the quantitative parameter (Ktrans) had significantly decreased in treatment responders, indicating that it may be a predictive parameter of the response to treatment.
Taking this into account, BMI might be a predictive parameter whether to use AI-based or tamoxifen-based endocrine treatment.
As this could not be shown for tamoxifen in these trials, BMI might be a predictive parameter regarding endocrine therapy.
Increased serum PCT levels may be a predictive parameter of infection and MOF development during AP and correlated with high mortality rate.
Da Rocha et al 15 found S100B to be a predictive parameter for fatal outcome in patients with IHI and in multi traumatised patients.
It has also been recently reported, during the 2005 San Antonio meeting, that MYC status could be a predictive parameter of tumour response to anti-HER2 therapy (Gianni et al, 2005).
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The O6-methylguanine-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide.
A small caliber artery ipsilateral to the ischemic region was a predictive parameter for FP versus TP discrimination (ROC area, 0.84 ± 0.04 vs. 0.59 ± 0.05; p < 0.0001).
In this reanalysis of the ABCSG-6a trial, we demonstrate that BMI is a predictive parameter regarding extended endocrine treatment with an AI.
Although adenocarcinoma is known to be a potentially poor prognostic factor in patients with resected NSCLC, the addition of chemotherapy revealed in previous studies an increased benefit for this histological subtype, allowing the hypothesis that this parameter may be a predictive factor for enhanced multimodal treatment benefit [ 29].
Indeed, preclinical studies have also shown that pretreatment dCK expression level could be used as a predictive parameter of tumour sensitivity and a clear correlation between dCK activity and gemcitabine sensitivity was observed in several tumour xenografts (Kroep et al, 2002).
More suggestions(17)
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