Genetic variability possibly predicts treatment outcome and could be a predictive marker to select the group benefiting from a certain treatment.
First, CTC can survive chemotherapy and therefore can be a predictive marker for the effectiveness of treatment.
KRAS mutation status has been reported to be a predictive marker of tumor response to epidermal growth factor receptor (EGFR) inhibitors.
For example, somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor was shown to be a predictive marker for a greater efficacy of gefitinib in patients with non small cell lung cancer [7, 8].
This study was designed to investigate whether interleukin 6 (IL-6) in cerebrospinal fluid (CSF) in the early phase of carbon monoxide (CO) poisoning can be a predictive marker of delayed encephalopathy (DE).
MMP8 was also detected in the chorion during labor and was proposed to be a predictive marker for preterm delivery [39], [40].
The ability of the H1N1 vaccine to prevent virus replication in the lungs of mice may be a predictive marker for disease prevention in humans.
Although MGMT methylation status appears to be a predictive marker of response to TMZ in patients with newly diagnosed GBM [7], there have been several issues which have prevented widespread adoption of this marker in clinical practice.
Males heterozygous for R462Q have a 1.5-fold elevated risk, and homozygous men double the risk of developing prostate cancer, suggesting R462Q to be a predictive marker for the malignancy [13].
Therefore, loss of AF-6/afadin might be a predictive marker of chemoresistance to cisplatin.
Further studies are needed to clarify whether EG-VEGF could be a predictive marker of PE.
