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We hypothesize that cellular biomechanics can be a predictive biomarker of endothelial health.
Hyper-activation of STAT3 is proposed to be a predictive biomarker of trastuzumab resistance.
Similarly, Boni et al. identified thymidylate synthase as another target of miR-215-5p miR-215-5p miR-215-5p be a predicthat biomarker for 5-FU response in CRC.
Soluble receptor of advanced glycation end-products (sRAGE) may be a predictive biomarker in coronary artery disease (CAD).
These suggested that the pretreatment level of circulating free IGF gives an estimate of IGF bioactivity and might be a predictive biomarker of the response to anti-IGF-1R antibodies.
Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM.
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The KRAS-variant predicts increased cancer risk for certain populations, is a predictive biomarker of cancer treatment response across cancer types, leads to conserved tumor biology and elevated AKT signaling in KRAS-variant patient tumors, and was recently found to predict elevated TGF-β and immunosuppression in cancer patients.
Bauer, Y. et al. MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis.
Further confirmation that mutational load is a predictive biomarker for immune therapy came from Hugo et al.11 demonstrating that survival after PD1-inhibition treatment is associated with mutational load.
All genetic alterations identified were stratified based upon prior evidence that the mutation is a predictive biomarker of drug response using the MSKCC OncoKB classification.
Expression of ENTs is a predictive biomarker for drug efficacy in cancer treatment (Giovannetti et al., 2006; Borbath et al., 2012; Nordh et al., 2014; Pastor-Anglada and Perez-Torras, 2015; Svrcek et al., 2015).
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