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Amongst the genes displaying significant sexually dimorphic expression, nine genes were histone-modifying enzymes, suggesting that epigenetic mechanisms might be a potential underlying regulatory mechanism.
Although there is no evidence for implantation of embryos in the mouse oviduct, embryos can implant in the human Fallopian tube, and this could be a potential underlying mechanism for ectopic pregnancy.
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A recent study by Yang et al. (55) found increased mucosal mast cell numbers, serum tumor necrosis factor-α, rectal sensitivity, and anxiety in lactose intolerant IBS-D patients, supporting that neuro-immune modulation of visceral function is a potential underlying mechanism.
The Hypothalamic-Pituitary-Adrenal (HPA) axis has been proposed as a potential underlying biological mechanism linking prenatal depression with adverse offspring outcomes.
Earlier studies linked prenatal arsenic exposure to increased risk of infant mortality, and infectious disease has been suggested as a potential underlying cause in these deaths.
The Hypothalamic-Pituitary-Adrenal (HPA) axis of both the mother and child has been proposed as a potential underlying biological mechanism linking prenatal depressed mood with adverse offspring outcomes.
An alteration of the HPA axis of both the mother and child has been proposed as a potential underlying biological mechanism linking prenatal maternal mood disturbance with adverse offspring outcomes.
Our data suggest that attenuation of calcineurin NFAT signaling in neoplastic pancreatic ductal epithelium by a single extra copy of Dscr1 is sufficient to inhibit the progression of early PanIN lesions driven by oncogenic Kras, and thus may be a potential mechanism underlying reduced incidence of pancreatic cancer in Down syndrome individuals.
(21) The SDF-1 expression signature in patients with gastric cancer may be a potential mechanism underlying tumor heterogeneity.
Increased catecholamine levels in cardiac tissue are a common finding in DM [ 22] and hence may also be a potential mechanism underlying reduced ErbB receptor expression.
Epithelial-mesenchymal transition (EMT) induced by TGF-β is thought to be a potential mechanism underlying the development of pulmonary fibrosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com