In these investigations chelidonine turned out to be a potent inducer of apoptosis in Jurkat Vector cells inducing cell death in a concentration- and time-dependent manner (Fig. 14a and data not shown).
Some investigators have reported that nicotine can suppress neutrophil apoptosis; others have concluded that high nicotine doses did not influence apoptosis in freshly isolated peripheral neutrophils; while others have suggested showing nicotine to induce DNA cleavage in myeloid cells and to be a potent inducer of apoptosis in systemic neutrophils.
We found FPPa-OmoMYC to be a potent inducer of apoptosis (with IC50 from 1 2 µM) in TNBC cells with negligible effects in non-tumorigenic cells.
Cellular Fibronectin containing EDA has been found to be a potent inducer of cancer cell migration, invasion and scattering in vitro9.
Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations.
TNF is also known to be a potent inducer of mitochondria ROS.
Bacterial lipopolysaccharide (endotoxin) is a frequent contaminant of biological specimens and is also known to be a potent inducer of beta-chemokines and other soluble factors that inhibit HIV-1 infection in vitro.
On the contrary, L. plantarum DSM 15313 showed to be a potent inducer of IL-27 in the present study.
It is known to be a potent inducer of NF-κB and is also in turn unregulated by NF-κB.
Similarly TGF-β, which is considered to be a potent inducer of EMT both in normal and pathological conditions [17], [24], can cross-talk with TG2.
PMA has been shown to be a potent inducer of MMP and TIMP in experimental studies of blood-derived mononuclear cells [28], [41].
