Most, if not all, of the effects of the thrombin inhibitor have been ascribed to inhibition of thrombin, known to be a potent and pleiotropically active enzyme from the coagulation cascade.
Thus, from these findings, it can be concluded that the psychrophilic bacteria T. frigidphilosprofundus isolated from the deep marine environment were better producers of PGase as compared to the reported mesophilic and thermophilic counter parts and in the near future this would be a potent source of cold active PGase enzyme.
These promising results indicated that compound R-9k is a potent orally active GK activator, and is warranted for further investigation as a new anti-diabetic treatment.
STX243 is a potent orally active compound, as highlighted by the tumour growth inhibition studies.
Enzymatic measurements revealed that SMPDL3B is a potent phosphodiesterase active on the surface of these cells.
Uniconazole (S3307) is a potent and active member of the triazole family that was developed as plant growth retardants [ 22].
Atorvastatin is a potent intrinsically active inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase which is the rate-limiting enzyme in de novo cholesterol synthesis.
Olaparib (4- 3--4-fluorophenyl) methyl-1(2H)-one; AZD2281) is a potent, orally active, PARP inhibitor (Menear et al, 2008).
Lapatinib (LPT) is a potent orally active tyrosine kinase inhibitor, which blocks both epidermal growth factor receptor and HER2 (Rusnak et al, 2001).
Anastrozole is a potent, orally active, selective, non-steroidal AI that markedly reduces the levels of circulating oestrogens in postmenopausal women with breast cancer (Plourde et al, 1995; Geisler et al, 1996).
