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Upon searching the MTLD, pyridoxal kinase was found to be one of the targets of theophylline, which could be a possible underlying mechanism of the neurotoxic effects of theophylline [26].
This may also be a possible underlying mechanism of free fatty acid induced impaired GSIS in human islets shown during perifusion [47] as well as during static incubation [48].
Thus, this deficient glucose level compounded with the inability of brain cells to handle the available glucose (as demonstrated here) may likely be a possible underlying mechanism for neuronal degeneration in METH abuse.
Local enhancement would thus be a possible underlying mechanism that could explain some of the results.
This could be a possible underlying mechanism to the low-to-modest activity of farnesyltransferase (FTase) inhibitors in clinical phase II and III studies (Sebti and Adjei, 2004).
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An up-regulation of this intestinal transporter is a possible underlying cause of this disorder.
A premutation syndrome (55 200 repeats) has also been reported with elevated FMR1 mRNA and reduced FMRP levels, where RNA toxicity is a possible underlying molecular mechanism (Garcia‐Arocena & Hagerman, 2010; Bagni et al, 2012).
This verified that potential changes, such as compensatory increases or decreases (e.g. due to loss of heterozygosity) did not occur in HGF+ × [ m1m2]+/− tumors and were not a possible underlying cause of their increased metastatic potential.
Hence, health care professionals confronted with children with an associated disorder in conjunction with nasal regurgitation, other feeding difficulties or symptoms as described above should be aware of a possible underlying CP.
Thus, drug-induced autophagy was investigated as a possible underlying mechanism of the anti-inflammatory effects of brominated noscapine analogs.
Interactions between Bw4 and KIR3DL1 have been proposed as a possible underlying mechanism to explain the relationship between HLA-B and BD.
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