Therefore, recovery of NEP expression in patients with AD may be a possible strategy for AD therapy.
Taking all of these findings into consideration, pharmacological intervention in cholesterol metabolism might be a possible target in AD treatment.
An impairment of proteasome activity was earlier reported in patients with AD which could be a possible reason for the elevation of BACE1 during AD pathogenesis (Upadhya & Hegde, 2007).
Thus, the inhibition of S100a9 is a possible target for AD therapy.
Tetracyclines inhibit Aβ amyloid formation and are considered possible AD drugs.
It is possible AD reflects infection and inflammation in association with the cerebrovasculature, whereas ATH is the result of infections propagating in the peripheral vasculature.
In the original Beach et al. analysis, subjects were diagnosed with possible AD (n = 126) using NINDS-ADRDA guidelines [ 26].
Patients with suspected INPH and cognitive impairment should therefore be routinely evaluated for possible AD by a clinician skilled in the diagnosis of neurodegenerative disorders (Class IIa). 2. Patients presenting with an isolated dementia syndrome rarely have INPH.
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Moreover, it is likely there are important ramifications for those who are not diagnosed with probable or possible AD but are later found to have AD-related pathology (which is often mixed).
