Sentence examples for be a physiological target from inspiring English sources

Furthermore, knockdown of PP2c gene did not affect the morphology and the growth of the T. brucei PCF cells (data not shown), suggesting that PP2c may not be a physiological target for T. brucei 14-3-3 14-3-3 14-3-3ivo.

To determine if Rpb1p could be a physiological target, we replaced the native rpb1 gene with a synthetic gene encoding a Rpb1p protein in which Ser-2 was substituted with the non-phosphorylatable amino-acid alanine in all heptads.

It has been suggested that ALY could be a physiological target of nuclear PI3K signaling, which regulates ALY's subnuclear residency in speckles, as well as, cell proliferation and mRNA export activities through nuclear Akt phosphorylation and phosphoinositide association [ 25].

Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target.

These results establish that ENT4 is a physiological target of EWS/WT1 and is highly expressed by the tumor cells of DSRCT.

We demonstrated that one of the predicted substrates, SIN1, is a physiological target of Akt.

Considerable evidence indicates that vascular endothelium is a physiological target of insulin and a potential link between insulin resistance and atherosclerosis [ 33, 34].

Interestingly, studies on DAX-1 deficient mice, displaying an increased aromatase expression, indicate that P450aromatase is a physiological target for DAX-1 in Leydig cells.

We show here that cathepsin C is a physiological target of cystatin F but only once cystatin F has undergone post-translational proteolytic processing.

Taken together with the CRMP and CDK5 co-expression data (Additional file 2: Figure S3) this indicates that Ser522 of CRMP2, but not CRMP4, is a physiological target for CDK5.

Phosphorylation of mGS at site 2 occurs in response to AICAR treatment of muscle of wild-type mice, but not AMPK-α2 knockout mice, showing that this site is a physiological target for AMPK (Jorgensen et al., 2004).