This observation suggests that a combination of Y64H mutant amelogenin and ameloblastin is a pathological factor in these transfected cells that might also be present in vivo in the M100888 mutants.
Tumor necrosis factor (TNF) is one of the important cytokine that has long been considered as a pathological factor implicated in the pathology of dozens of human diseases, including septic shock [ 7], cancer [ 8], rheumatoid arthritis [ 9], malaria [ 10] and other afflictions.
It is well known that atherosclerosis (AS) is the leading cause of death in most Western countries, and is a crucial pathological factor in the development of cardiovascular diseases, leading to alterations and lesions in the inner walls of blood vessels [ 1].
Thus, deficient adult neurogenesis is a significant pathological factor in AD and our findings suggest that therapies against AD will be more effective when supplemented with treatments that stimulate adult neurogenesis (such as exercise) or prevent impaired adult neurogenesis (such as anti-inflammatory drugs).
LAT1 expression is a promising pathological factor to predict the prognosis in patients with resectable stage I III NSCLC.
Together, these pieces of evidence indicate that HBV infection is a critical pathological factor in the autophagy-miR-224-Smad4 autophagy-miR-224-Smad4 autophagy-miR-224-Smad4 autophagy-miR-224-Smad4
Current evidence indicates that RUNX2 is a key pathological factor in metastatic breast [ 8- 17], prostate [ 18- 22] and bone [ 23- 31] cancer cells, as well as in lymphomas in mouse models [ 32- 35].
Because bone resorption is a major pathological factor in arthritis and treatment with VIP significantly reduced the incidence and severity of arthritis in the CIA model [ 22], the aim of this study was to analyze the effects of VIP treatment in vivo on different mediators that interfere with bone homeostasis in this animal model.
The emerging view is that toxic amyloid-β oligomers (AβOs) are an important pathological factor in early neurodegenerative events in AD [ 37].
Evidence suggests that poor sleep quality is an important pathological factor in the onset of T2DM [ 3– 9] and also in CVD [ 10] in non-T2DM subjects.
