Notably, other familial PD-linked gene products, parkin [61], DJ-1 [63], [63], and PINK1 [65], [65] are also associated with Akt signaling, supporting an intriguing notion that alterations in Akt signaling may be a common pathologic factor in PD.
These data suggest that miR-21 could be a new pathologic factor and potentially a therapeutic target in cardiovascular disorders, including complicated pregnancies with increased vascular resistance.
Overall, we found that Glx within the posterior gyrus was a potential pathologic factor in FM, and we speculate that myoinositol might, through its conversion to glucuronic acid, be consumed in the protective detoxification reactions of the brain.
These studies do provide support for the hypothesis that dysfunctional T cells are a key pathologic factor in lethal fungal infections.
Both cytokines are critical mediators of mucosal inflammation; accordingly, IL13 secreted by natural killer T cells is an important pathologic factor for ulcerative colitis [ 57].
Pathologic complete response (CR) to preoperative chemotherapy has been shown to be a strong prognostic factor in resected non-small cell lung cancer (NSCLC).
10, 15, 19 Tumor size, tumor location, and lymph node status are three pathologic factors consistently shown to be associated with NAC involvement.
Apoptosis is believed to be an important factor in vascular remodeling in normal and pathologic conditions [19].
Finally, MD proved to be an important risk factor for all pathologic subgroups.
