Sentence examples for be a pathogenic role from inspiring English sources

Therefore, there is still a need to establish whether there may be a pathogenic role of sPLA2 enzymes in RA.

On the basis of these findings, they speculated there was a pathogenic role for MR-aldosterone in retinal inflammation.

As the number of TDP-43 inclusions in ALS cases, with and without the C9ORF72 mutation are nearly identical we can find no evidence that dipeptide repeat proteins are playing a pathogenic role in ALS-C9+ve cases.

These genes modulate several mechanisms (discussed below) that are serving a pathogenic role in AD.

Insoluble Aβ, amyloid plaques and plaque-associated neuritic dystrophy have all been assigned a pathogenic role with abundant evidence linking the extent of learning and memory impairment as well as behavioural deficits to amyloid burden and the amount of insoluble Aβ in APP-expressing mice.

Interestingly, this is not consistent with in vivo findings, which are supportive for a pathogenic role of IgA β2GPI-dependent aPLs in mediating thrombus formation [ 23].

Although ELF3 is thus infrequently mutated (6.9%% borderline tumors and 6.5 % carcinomas), the shared characteristics of the four heterozygous mutations is indicative of a pathogenic role.

Evidence is presented for a pathogenic role of the agrin/neurotrypsin system in a substantial subset of sarcopenia patients.

In human CM, ROS have been associated with a pathogenic role thus far.

Increased levels of ET-1 in plasma and bronchoalveolar lavage of some sarcoid patients are consistent with a pathogenic role in both pulmonary fibrosis and sarcoidosis associated PH.

The early onset of BC in both families, the occurrence of bilateral BC and the triple-negative tumor phenotype resemble features closely associated with hereditary BC [ 5], and thus the presence of a clearly truncating mutation is supportive for a pathogenic role of RAD51C.