Sentence examples for be a pathogenic event from inspiring English sources

Our results suggest that the selective loss of LCIs may be a pathogenic event in DYT1 dystonia.

Thus, the recurrent nature of the DDR1R570Q mutation across studies suggests it may be a pathogenic event that provides a selective advantage in tumorigenesis, including endometrial tumorigenesis.

A recent body of evidence has begun to emerge suggesting that aberrant sister chromatid cohesion may be a pathogenic event that underlies CIN and drives tumor development.

Collectively, these data strongly suggest that RAD21 over-expression may be a pathogenic event in a variety of tumor types, including HL. AOnly the Cancer Genome Atlas (TCGA) data is shown [ 21- 24].

However, they do not address the possibility that hypo- or hyper-morphic expression may occur and be a pathogenic event, as has previously been reported in other tumor types [ 7, 21- 24].

They further show that misregulation of mitotic increases in H3K79me2 is associated with genome instability and supports the possibility that aberrant regulation of mitotic H3K79me2 levels may be a pathogenic event that contributes to tumorigenesis.

Chromosome instability manifests as an abnormal chromosome complement and is a pathogenic event in cancer.

For over a century, it has been suggested that abnormal chromosome numbers are a pathogenic event that are associated with and drive cancer development [ 1].

These findings have suggested that a depletion in EPCs is a pathogenic event that, through the inability to maintain an intact endothelium and to promote angiogenesis, translates risk factors into the development and progression of CVD [ 5].

The retention of modified low-density lipoproteins is felt to be a key pathogenic event and possibly an absolute requirement for lesion development and progression [ 14, 15].

IFN-γ increases the sensitivity of Fas-mediated apoptosis of keratinocytes, which is considered to be a key pathogenic event in eczematous dermatitis [ 5].