Sentence examples for be a partial agonist from inspiring English sources

Therefore capadenoson could be demonstrated to be a partial agonist at the adenosine A1 receptor.

S-cyanopindolol was found to be a partial agonist at all three turkey β-adrenoceptors and stimulated an agonist response that was best described by a two component response at both the tβtrunc and tβ4C-receptors, but a one-component response at the tβ3C-receptor (Figure 8, Table 5).

The mechanisms of action may be a partial agonist on D2 and 5-hydroxytryptamine 1A receptors and an antagonist on 5-hydroxytryptamine 2A receptors [ 13].

Notably, and because UK14304 is largely reported in the literature to be a partial agonist at the α2B-AR subtype, we repeated these experiments with another, full α2B-AR agonist, oxymetazoline, and the results were identical (data not shown).

Bucindolol has been shown to be a partial agonist at the human β1-adrenoceptor in human myocardium (37, 45, 56), and this partial agonist action has been reported to occur via the secondary site of the human β1-adrenoceptor (45).

Quipazine, for example, was originally considered an antagonist because of the apparent absence of inwards currents (later reported to be <1.6% the size of maximal 5-HT currents) and the long-lived inhibition of subsequent agonist responses; it was more recently shown to be a partial agonist by co-applying the allosteric modulator trichloroethanol (Downie et al., 1995).

Just as bupe is a "partial agonist" of opiate receptors, Chantix partially binds to nicotinic receptors, reducing cravings while simultaneously making smoking less pleasurable.

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.

Because it is a partial agonist, it has a ceiling effect.

Cytisine is a partial agonist at α4β2* and α6β2* nAChRs and a full agonist at α3β4* and α7 nAChRs (Salminen et al, 2004; Grady et al, 2010).

This medication (Subutex) is a partial agonist for opioid receptors, which means it is less efficient than a medication like methadone.