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There should be a mutant gene driving the time series change according to genetics point of view, but so far it has not been found, having difficulty in mathematical revealing the inherent mechanism of variation of the rolling bearing performance.
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Cystic fibrosis is caused by a mutant gene that prevents cells from producing healthy digestive juices, sweat and mucus.
Lesch-Nyhan disease is caused by a mutant gene on the X chromosome.
The disease is caused by a mutant gene in chromosome pair 18.
For this approach, genetic engineering is used to generate a mutant gene that no longer can express the protein it normally produces, and that nonfunctional (knockout) gene is inserted into the genome of test animals.
Center scientists examining cells belonging to Crohn and another gay man who had avoided infection discovered their immunity was the gift of a mutant gene, which prevented the virus' deadly infiltration by blocking a crucial portal into white blood cells.
These forms of macular degeneration, with the exception of Stargardt macular dystrophy, are inherited as autosomal dominant traits; disease occurs when a mutant gene is inherited from one parent.
In recessively inherited disorders, two copies of a mutant gene are necessary for the disorder to manifest; if only one copy is inherited, the offspring is not affected, but the trait may continue to be passed on to future offspring.
However, the effect of a dominant mutation can be monitored in cells transduced with a mutant gene while the endogenous gene product is knocked down by RNA interference [27].
If a mutant gene is part of the X chromosome, the resulting disease is called X-linked.
For example, a mutant gene might be 'covered' by a CNV in a given individual, so that the expected clinical phenotype would be masked by the presence of an additional wild-type copy in cis to the gene in question.
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