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Molecular pathways involved in tumour survival and progression are often enacted by genetic alterations, and cancer progression is thought to be a multistep acquisition of genetic and epigenetic events in tumour cells (Gerlinger et al, 2012).
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This function appears to be a multistep process that involves PINK1.
Whether this tolerance was associated with multidrug tolerance or whether acquisition of multidrug tolerance is a multistep process remains to be clarified.
Since the acquisition of metastatic phenotype is a multistep event, the HIF-1α associated perinecrotic processes of both tumor cell survival and death and LPS-mediated inflammatory response could indirectly contribute to this endpoint.
Focusing their study on EMB, they observed that acquisition of high-level resistance to EMB is a multistep process.
The Ebola P.S.A.s are a multistep project.
Training was closely supervised; execution was a multistep, labor-intensive process most efficiently carried out by groups.
His goal, he said, was a multistep move toward calm, in line with recommendations made in April by an international commission led by a former United States senator, George J. Mitchell.
"Usually, I tell them that there are a lot of factors that combine -- it's a multistep process," Dr. Winn said.
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CEO of Professional Science Editing for Scientists @ prosciediting.com