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Migraine is known to be a multifactorial disorder, with genetic, hormonal, environmental, dietary, sleep and psychological aspects playing a different role in each individual [1], it is considered a bio-behavioural disorder [2].
Indeed, to date, the many proteomics and transcriptome approaches have provided a wealth of data suggesting that the contraction of the D4Z4 repeat array is not sufficient to cause the disease and that FSHD is likely to be a multifactorial disorder (reviewed in [12]).
Male infertility can be a multifactorial disorder.
LDD is considered to be a multifactorial disorder involving numerous genetic and environmental factors and their interactions.
Atherosclerosis appears to be a multifactorial disorder, in which the classical Framingham factors, aging and poorly controlled diabetes are independent risk factors for the development of atherosclerosis.
SCH seems to be a multifactorial disorder, in which the contribution of both genetic and environmental factors and their interplay are important [ 1, 3].
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Obesity is a multifactorial disorder which is closely associated with hyperlipidemia.
Clinical studies have revealed that diabetic retinopathy is a multifactorial disorder.
Preterm birth (PTB) is a multifactorial disorder, and air pollution has been suggested to increase the risk of occurrence.
Recent studies support the idea that chronic TMD is a multifactorial disorder, in which psychological factors play an important role in the onset and development of the pathology.
It is well documented that headache is a multifactorial disorder which includes not only genetic, medical and neuropsychological factor but also psychological and personality traits.
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