Sentence examples for be a multifactorial defect from inspiring English sources

The interferon regulatory factor 6 gene (IRF6) is one of the most conspicuous genes among a large number of candidate risk genes for non-syndromic cleft lip with or without cleft palate, which is considered to be a multifactorial defect.

Male infertility can be a multifactorial disorder.

PWD is considered to be a multifactorial disease [ 4, 5].

PCS appears to be a multifactorial condition of unknown aetiology.

Type 2 diabetes is a multifactorial metabolic disease characterized by defects in β-cell function and insulin action and increased hepatic glucose production. 1 Metabolic dysfunction in type 2 diabetes is also the product of reduced glucose effectiveness or the ability of glucose to transport itself by a mass action effect.

Cleft lip with or without cleft palate (CL/P) is one of the most common birth defects; it is a multifactorial disease affecting > 1/1,000 live births in Europe, and its etiology is largely unknown, although it is very likely genetic and environmental factors contribute to this malformation.

The data also suggest that BPD is a multifactorial disorder characterized by multiple pathway defects as opposed to one overriding abnormality.

Type 2 diabetes mellitus is a multifactorial disease with a complex pathophysiology that includes defects in insulin production and a failure in peripheral tissues to take up glucose in response to insulin.

Type 2 diabetes is a multifactorial disease characterised by chronic hyperglycaemia as a result of defects in insulin secretion from the pancreatic beta cells and insulin action in target tissues including skeletal muscle, adipose tissue and liver.

However, HRR is a multifactorial process, and screening for BRCA mutations alone is likely to underestimate the proportion of cancers with HRR defects that could potentially benefit from PARPi therapy (McCabe et al, 2006).

Microinstability is a multifactorial entity.