Blinding is not possible as the intervention is a multifactorial approach.
Male infertility can be a multifactorial disorder.
Neuropathic pain should be managed with a multifactorial approach using drugs that act on different components of pain, including disturbed neuronal activity (anticonvulsants [ 28- 32] and local anaesthetics [ 33]), potentiation of descending inhibitory pathways (antidepressants [ 34]), or centres involved in the development and conduction of nociceptive responses (analgesics [ 35- 37]).
Elements that were demonstrated to be promising in different intervention studies are a multidisciplinary, multifactorial approach with tailor-made interventions and an individual assessment for frail older people provided by a (primary) care team with long-term follow-up [ 17- 19].
The existing literature indicates that lifestyle interventions in primary care aimed at patients at low CVR cardiovascular risk are barely effective or, at least, there is no sufficient evidence on their effectiveness when a multifactorial approach is used [ 47, 48].
Diet and lifestyle modifications are often ineffective to manage constipation in the elderly and a multifactorial approach is suggested.
The traditional screening kit method and a multifactorial approach were compared against each other with regard to their ability to find new crystallization conditions that are compatible to the purification process of a recombinant aprotinin variant.
Ultimately, NMCP is complex and often requires a multifactorial approach for optimal management [ 32].
A multifactorial approach is needed for the management of risk factors (i.e. total cholesterol, hyperglycaemia and anaemia, as well as blood pressure) in patients with diabetes.
This highlights that to bring behavioral change implementing a multifactorial approach is needed, which also targets other important facets, such as the sustainability of CVDs control programs.
