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Among intracellular metabolites, α-keto acid such as αKG turns to be a master regulator for catabolite regulation and co-ordination of different regulations [139].
Scleraxis may thus be a master regulator for tenocytes, and regulation of fibrillar collagen synthesis may represent one aspect of this role.
This miRNA would appear to be a master regulator for several aspects of immunity, including the regulation of cytokines, such as tumor necrosis factor-alpha (TNF-α), functioning in the negative feedback control of innate immunity in Toll-like receptor (TLR) signaling, and is involved with T-cell activation and is highly expressed in mature human memory T cells [ 41].
The similar induction pattern of all tested conglutin genes suggests that their expression may be regulated by a common mechanism and there may be a master regulator(s) to ensure overall protein quantity within the seed is maintained.
Smarr learned that he had DNA aberrations on a gene that several studies suggest may be a "master regulator" in Crohn's, and which, by exacerbating the immune system's inflammatory response, confers a greater than average risk for the disease.
mTOR is believed to be a master regulator of skeletal myogenesis by controlling multiple processes through different mechanisms.
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While the mitochondrion is a master regulator of PCD in animals, the chloroplast is known to regulate PCD in plants.
ATF6 is a master regulator of the unfolded regulator response and has been implicated the regulation of lipid metabolism [ 52].
Snail is a master regulator of epithelial mesenchymal transition (EMT).
Runx3 is a master regulator critical for CD8+ T cell development (Woolf et al., 2003).
CTCF is a master regulator that plays important roles in genome architecture and gene expression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com