Sentence examples for be a major underlying from inspiring English sources

The current study, therefore, reveals that desolvation can be a major underlying cause for the apparently counterintuitive structure-activity relationship (SAR) outcomes, and indicates that understanding this factor can improve our ability to predict binding affinity and to design more potent ligands.

An aberrant histone methylation pattern may be a major underlying mechanism for sustained proinflammatory phenotype of diabetic cells.

Changes in dietary pattern have shown to be a major underlying factor for increasing prevalence of obesity and associated NCDs.

Electron transport chain dysfunction associated with deletions involving mtDNA protein-coding genes is thought to be a major underlying cause of the degenerative phenotypes associated with aging, mitochondrial myopathies, and other human disorders (Conley et al. 2007).

Insufficient access to health technologies substantially impairs health workers' ability to deliver minimum standards of care and, as a result, technology scarcity is recognized to be a major underlying cause of maternal and newborn deaths [ 20- 22].

Similar to ERα, the results confirm that in the high percentage of breast cancers that express AR, gene amplification does not seem to be a major underlying genetic change.

In all these species, predation is assumed to be a major factor underlying polymorphism.

Our data, however, point that autophagy might be a major mechanism underlying the effects of thioridazine.

In this regard, emerging evidence indicates that upregulation of angiopoietins may be a major mechanism underlying the inadequate therapeutic effects of VEGF-A pathway blockage [ 9, 22].

A number of studies have suggested that loss of p53 function may be a major reason underlying failure to respond to chemotherapy (Ferreira et al, 1999).

Indeed, the upregulation of angiopoietins may be a major mechanism underlying the inadequate therapeutic effects of VEGF-A pathway blockage [ 9, 22].