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It would be a major setback for China, and the global economy, if the long and proven track record of spectacular Chinese growth were to be undermined by waiting too long to make progress on financial liberalization and reform.
McCain's plan to erode the role of employers in providing health care by changing the tax structure, might be a major setback in the process of health care reform, he suggests.
At 23 and 25 respectively, a loss at this stage would not be a major setback.
Its failure would be a major setback to progressivism and integration in the Middle East.
The outcome appeared to be a major setback for Democrats, who control the Senate.
A major setback for Tyndall would be a major setback for her.
It would also be a major setback for what economic and political integration has already been achieved.
If taken, it could be a major setback to the Shabab by cutting off their supply line.
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Ms Gupta says the Congress is "mentally prepared" that they will not win this election, and even a poor tally will not be a major setback for the Gandhi scion.
A European foreign minister, in a conversation last month, said that the "blowing up" of Israel's alliance with Turkey would be a major setback for the region.
A rejection tonight would be a major setback to the mayor and the chancellor, at a most difficult time.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com