Sentence examples for be a major pathophysiological from inspiring English sources
Moreover, calcium overload subsequent to disturbed sodium homeostasis may also be a major pathophysiological factor in diastolic heart failure.
Proinflammatory cytokines, particularly IL-1β and TNFα, are currently believed to be generated in the periphery, to communicate with the brain and to initiate cytokine synthesis within the central nervous system, and this is thought to be a major pathophysiological step underlying brain dysfunction [ 20].
Hypoxia is a major pathophysiological trigger of angiogenesis.
When coupled with β-cell dysfunction, IR is a major pathophysiological determinant of dysglycemia (impaired fasting glycemia, IFG, and impaired glucose tolerance, IGT) and T2D [13], [13].
Another difference that might contribute to ethnic variance in insulin secretory capacity could be impaired incretin action, which is a major pathophysiological characteristic of T2DM [ 60– 60].
This model takes into account the inflammatory [ 23] and metabolic (hyperglycaemia) pathways that are a major pathophysiological process and disturbance of septic shock, respectively.
Impaired insulin action (insulin resistance) in combination with impaired insulin secretion is a major pathophysiological mechanism leading to elevated fasting or postprandial glucose in pre-diabetic individuals.
They also illustrate that increased production of LDL is a major pathophysiological contributor to the profoundly elevated levels of LDL in homozygous FH as indeed has been repeatedly documented [ 4, 9, 11– 11].
Chronic ER stress has been considered to be a major contributor to pathophysiological changes in cardiovascular diseases [ 16].
Statins are beginning to be used in a number of clinical situations where inflammation is considered a major pathophysiological mechanism including in people undergoing CPB.
Disorders of gastrointestinal (GI) motility are considered a major pathophysiological mechanism underlying symptoms of functional GI disorders.
