Sentence examples for be a major pathological from inspiring English sources

Preliminary studies of the major pathogen enterovirus 71 (EV71), a member of the Picornaviridae family, have suggested that EV71 may be a major pathological cause of fatal hand, foot and mouth disease cases by inducing significant pathological changes in the central nervous system (CNS) that ultimately lead to neurogenic pulmonary failure.

The death of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD).

These results suggest that caspase-cleaved TDP-43 is a major pathological finding in AD and may contribute to the neurodegeneration associated with this disease.

The aggregates of α-synuclein (αS) are a major pathological hallmark of Parkinson's disease (PD) making their structure-function relationship important for rational drug design.

Systemic sclerosis (scleroderma, SSc) is a complex autoimmune disease in which excessive accumulation of extracellular matrix (ECM) in the skin and internal organs is a major pathological finding.

In AD, the accumulation of Aβ, especially Aβ42, is a major pathological change [7], [8], [36] and the abnormality in neuronal synchronization is well described [4], [5].

Therefore, white matter changes are a major pathological characteristic of FTD (Larsson et al., 2000, 2004).

Amyloid-β (Aβ) plaques are a major pathological hallmark of AD.

Protein aggregation is a major pathological hallmark of many neurodegenerative disorders including polyglutamine diseases.

ASM proliferation and migration is a major pathological component in airway remodeling of asthma.

The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD).