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The C. jejuni flagellar apparatus has been reported to be a major pathogenicity determinant [ 25, 26, 48].
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The polysaccharide capsule is a major pathogenicity factor in pneumococci, and antibodies directed against it represent a major defense mechanism against this pathogen.
These pathogens may have a greater degree of pathogenicity (although Stenotrophomonas is generally not considered to be a major pathogen), or may be more difficult to treat.
The amino acid sequence of the HA1/HA2-connecting peptide of HA is a major determinant of pathogenicity in terrestrial poultry, and the pathogenicity of highly pathogenic subtype H5N1 and H7N3 viruses is influenced by the presence of a polybasic cleavage site in the connecting peptide (32 ).
It has therefore been argued that binding to nucleosomes is a major determinant of pathogenicity of autoantibodies in LN [ 13, 14].
The sequence of the F protein cleavage site is a major determinant of NDV pathogenicity in chickens because it plays a major role in determining where and how the F0 precursor is cleaved [1], [50].
Accessibility to glycoprotein cleavage is a major determinant of IAV pathogenicity (Bosch et al., 1981).
Other evidence suggests that the adeptness of A. fumigatus to acquire iron from the host is a major basis of its pathogenicity.
In conclusion, the expression of HC-Pro gene alone largely simulates the effects of a virus infection in plants, indicating that it is a major factor in viral pathogenicity.
The high degree of polymorphic variability is a major disadvantage in assessing the pathogenicity of a new base change.
As bacterial pathogenicity is a major concern for the public, we have customized and incorporated in ListeriaBase, our in-house designed Pathogenomics Profiling Tool (PathoProT), allowing users to identify the putative virulence genes and compare the virulence profiles across different Listeria strains [ 49].
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