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DUSP1 appears to be a major feedback regulator of the innate immune response, and to play a critical role in preventing septic shock and multi-organ dysfunction during pathogenic infection [36].
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This so-called ice-albedo feedback is believed to be a major reason that the Arctic is warming so rapidly.
The ice-albedo feedback is thought to be a major reason why the Arctic is warming so rapidly.
Rpn4, in addition to being a major mediator of core Rpn4-proteosome feedback circuit also appears to be a major mediator in a stress response network (Xie, 2010).
Monitoring, Evaluation and Feedback: It is reported to be a major issue during program implementation.
It is therefore likely that the PD-1/PD-L1 signaling pathway is a major negative feedback regulator of antigen responsiveness (Okazaki et al., 2013; Honda et al., 2014).
These are complex effects, but the modelling does suggest that while "stress" inputs may reduce over time hormone negative feedback is a major factor reducing hormone responses.
Waiting until the end of the year to provide feedback is a major fail.
Uncertainty over the effect of feedbacks is a major reason why different climate models project different magnitudes of warming for a given forcing scenario.
A new design methodology have been developed that do not use the Schauder fixed point theorem, which is a major limitation of existing nonlinear Quantitative Feedback Theory (QFT) methodology.
Our results strongly demonstrated that the positive feedback regulation is a major reason for the phase delay of the Per2 mRNA oscillation.
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