A gain of function polymorphism leading to increased platelet reactivity would likely be more prominent when studied in a setting were platelet activation is a main pathogenic factor, such as AMI.
Together, the above findings in normal and diseased muscle clearly indicate that a proper balance of the autophagic flux is essential for maintaining healthy skeletal muscle, and that unbalanced autophagy is a main pathogenic mechanism in many muscle diseases.
Mitochondria are a main source of potentially pathogenic reactive oxygen species (ROS) such as superoxide, particularly in highly metabolically active organs such as the brain and heart [1] [3].
The amyloid hypothesis is still debated and several arguments point against amyloid as a main pathogenic factor in AD pathology [ 49].
Axonal degeneration is a main contributor to disability in progressive neurodegenerative diseases in which oxidative stress is often identified as a pathogenic factor.
Liver fibrosis is a feature in the majority of chronic liver diseases and oxidative stress is considered to be its main pathogenic mechanism.
Candidates for this class of therapeutic agent are selected largely for their activities in other pathological conditions and our speculations as to other actions on what we suspect to be the main pathogenic pathways in DMD.
In conclusion, our data show that HCV infection could be the main pathogenic factor of lichen planus in Japanese patients.
The loss of genomic stability seems to be the main pathogenic key, appearing early in the carcinogenesis process.
Renal vascular remodeling, hyperplasia of the glomerular mesangium, and renal fibrosis have been considered to be the main pathogenic factors behind renal damage in hypertension [ 21].
