The latter p.E380G has been reported as an single-nucleotide polymorphism but might be a low-allele-burden somatic mutation in this patient because it was only detected after TA-cloning anotnot by Sanger sequencing on patient's genomic DNA.
Although endothelial cells are assumed to be genetically stable and have a low mutation rate, antineoplastic cytotoxic agents are regarded as inhibitors of angiogenesis [ 25].
The non-uniform survival rate of HD links can be explained by assuming a low mutation rate for a high-degree node, and thus this model appears to be biologically plausible.
Moreover, we found that mutations in BRAF and NRAS are not mutually exclusive because they were simultaneously present in the same tumor specimens and we observed that when the 2 different mutations were present one is a high-frequency mutation and the other is a low-frequency mutation.
These patterns of shared polymorphism may be the result of a low mutation rate, incomplete lineage sorting, or hybridization.
PanNET and Si-NET are both characterized by a low mutation rate compared to other tumor entities.
Because it is predominantly uniparentally inherited, has a low mutation rate, and does not recombine, it can be used to construct lineage genealogies that can be analysed in a spatial context [ 2, 3].
In fact, this hypothesis is likely to be true for spoligotypes, which have a low mutation rate.
These problems are likely to be most severe in genomes with a low mutation rate and low recombination rate, and less severe in genomes with very high mutation and recombination rates, such as HIV.
The Suppressor-mutator (McClintock 1957) or Enhancer/Inhibitor (Peterson 1953) family of transposons is similar to Ac/Ds with a low mutation rate and preference to transpose to linked regions (Gierl and Saedler 1989).
