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Other reasons for fractional occupancies could be a low affinity between POM and the protein, POM exhibiting multiple conformations or orientations (due to different binding modes) or low POM concentration leading to unsaturated binding.
The authors discussed the possibility that since AtCERK1 has been reported to be a low affinity chitin receptor, the low affinity of LysM2 is sufficient to compete and this explains how ECP6 can suppress innate immunity.
For example, in the barley GS family, HvGS1_3 has been proposed to be a low affinity isozyme because it lacks both of these residues and would therefore require a greater concentration of ammonia for maximal activity compared with HvGS1_1 and HvGS1_2 [ 26].
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A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling.
Attractin is a low affinity receptor for agouti, and both of these molecules regulate pigmentation.
CD23, also known as FcεRII, is a low affinity IgE receptor and the classical IgE receptor on B cells.
One study shows that cocaine is a low affinity antagonist at α7-nicotinic acetylcholine receptor (nAChR) while CM is a high affinity agonist of the receptor [22].
Although GR affinity of these steroids has not yet been determined, previous transactivation assays suggest that 21OH-6,19OP is a low affinity ligand, since only high concentrations ([10 µM]) are able to block Dex ([10 nM]) activity [48].
The OT-II transgenic TCR is a low affinity TCR, and recognizes the same antigen as the transgenic TCR carried by DO11.10 transgenic mice, albeit presented by a different MHC class II molecule [26].
p75NTR, a member of tumor necrosis factor receptor superfamily, is a low affinity neurotrophin receptor.
Imepitoin is a low affinity partial agonist at the benzodiazepine receptor [ 17].
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