Sirtuin 1 (Sist1) is a longevity gene that has protective effects in cardiovascular diseases (CVDs).
LAG1 is a longevity gene that was cloned from yeast [ 42].
SIR2 is a longevity gene and SIRT1 is its human homologue.
Overall, we conclusively showed that Sir2 is a longevity gene in Drosophila.
Of these GLY1, HIS6 and DAL1 are related to amino acid metabolism and PNC1 is a longevity gene [ 43].
We have demonstrated that deficiency in RasGrf1 expands not only average but also maximal lifespan, thus revealing to be a longevity-conserved gene in rodents and humans.
One evident example is Sirt1, a longevity gene that mediates calorie restriction (CR) benefits (Guarente, 2013), is involved in circadian regulation (Chang and Guarente, 2014; Jung-Hynes et al., 2010).
However, so far, GWAS for longevity in the LLS 37, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) 38, 39, NECS 40, German long-lived individuals 41, and SICS 42 have only identified one genome-wide significant (p < 5 × 10−8) locus: APOE, which has long been established as a longevity gene.
Given that SIRT1 was discovered as a homolog of a longevity gene, it is interesting to note the growing evidence for a link between Wnt/β-catenin signaling and age-associated diseases.
Gianni Pes, the Sardinian scientist who helped coin the term Blue Zone, is not convinced there is any such thing as a "longevity gene" that sets the populations apart.
