This is a long evolutionary distance by any account.
This may involve transient or sustained increase in the cellular level of chaperones, but the associated costs need not be a long term evolutionary handicap if populations are effectively small, making selection relatively inefficient.
It seems very unlikely that human beings would be endowed with sexual jealousy if there wasn't a long evolutionary history in which that behavior was in fact acted upon.
We also found that once the structure of miR genes is established it tends to be kept for a long evolutionary time.
Our results indicated that tandem duplication was the predominant contributor to the expansion of the soybean EXLA subfamily and 74% genes in EXLB that were involved in tandem duplication, and may be retained over a long evolutionary period.
On the other hand, most of the human-fugu CNEs which are conserved over a long evolutionary period (420 Myr) are likely to be under purifying selection.
The hexameric replicative helicase structure and loading mechanisms have been honed over a long evolutionary history to be highly efficient (Forsburg, 2004; Bae et al., 2009; Slaymaker and Chen, 2012) and probably very few errors occur in vivo.
It is a long running evolutionary issue how the complex, multicuspid mammalian dentition evolved in response to selective pressures related to feeding strategies, within constraints related to the phylogenetic history (e.g. [11], [12], [13], [14], [15]).
The proteins present in cells of modern animals and humans are products of a long evolutionary history, during which the ancestor proteins were naturally selected for their ability to fold into specific three-dimensional forms with unique functional surfaces useful for cell survival.
Hence, we can conclude that the function of the BDGs/BDTs is conserved in different species but that the BDGPs/BDTPs in new species are formed over a long evolutionary history rather than preserved as part of an ancestral heritage.
