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By averaging the simulation results across all ten age categories, we calculated the per-category empirical threshold for genomewide significance with a type I error rate of α = 0.05 to be a LOD score of approximately 3.1, likely reflecting the imperfect informativity of the 10K panel [37].
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In almost all cases where linkage groups were combined in this way, the recombination frequency between adjacent markers was 0.23 or lower, and the support for linkage was a LOD score of 3.7 or higher.
When the data from these four families were combined, a LOD score of 8.2 was achieved, which is highly significant.
Thus, although there seems to be a high potential for LOD, this option cannot be further promoted by doctors.
There was also a LOD score of 2.18 (p =.0008) at this region when all the ASD families were used.
Therefore, it is more revealing to examine framework maps where the best order is supported by a LOD ≥ 3 and is assumed to be reliable.
To date, however, linkage to a single gene has not been reported at a LOD that is much more significant than the marginal value of 3 in this Swedish study and the penetrance in this study was incomplete.
LOD is a reflection of planetary angular momentum and variability in LOD expresses changes in the angular velocity of atmospheric zonal winds [20].
Understanding the pathophysiology of LOD is a clear goal in achieving further advances in the therapy of LOD and prevents converting to dementia.
LOD is a parameter to the whole optimization process, and it will be locally and dynamically updated by each robot [1, 2].
Using a top-down conceptual approach they show that Level Of Detail (LOD) is a crucial element in defining the content of a BIM use.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com