There did not appear to be a linear dose response relationship between 8-OHdG and TUA.
There appeared to be a linear dose response for overall AEs, but not for individual AEs, although evaluation of a dose response relationship for particular AEs was precluded by the open-label design and the allowance of flexible dosing throughout the study.
Although other studies have also used trauma-exposed control groups, [35] there appears to be a linear "dose response" association between trauma load and PTSD symptoms, [38] such that even trauma exposed individuals without PTSD may have significantly lower levels of trauma than individuals who meet DSM criteria for PTSD.
Despite these findings, there did not appear to be a linear dose-dependent relationship between drug resistance and drug accumulation.
In agreement with previous studies with monoclonal and polyclonal antibodies26,27,28, there was a linear dose response for each mAb when the ratio of mean oocyst count (right y-axis, on a log-scale) was plotted against the square root of antibody concentration (x-axis).
We included the lower N2O concentration in our study to see if there was a linear dose response.
Breast cancer risk was inversely related to age at exposure, there was a linear dose response, and the minimum latency period was 12 years (Land et al, 2003).
To test whether there was a linear dose effect of the variant alleles (log-additive genetic model for trend test), SNPs were coded as 0, 1, and 2 as described above.
The hypothesis that there is a linear dose response relationship between FK778 dose and increasing efficacy could not be proven in this study; increased exposure to FK778 did not result in increased efficacy in terms of acute rejection rates, or less treatment failure or better renal function.
There is a linear dose-risk trend of esophageal squamous cell carcinoma with alcohol consumption [ 35, 41, 45, 46]; the dose of alcohol consumed per day or week appears to be the most important determinant of risk, and not the duration of the habit [ 41, 43, 47, 48].
There is a linear dose-response relation between fasting blood glucose concentration and the rate of pancreatic cancer across prediabetes and diabetes, with every 0.56 mmol/L increase in fasting blood glucose associated with a 14% increase in the rate of pancreatic cancer.
