This was a large multicenter study, and the majority of data were prospectively collected.
The National Emergency X-Radiography UtilizatioNEXUSdy II (NEXUS is) is a large, multicenter, prospective study designed to derive a decision rule for CT imaging of patients with blunt head injury.
The China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) was a large, multicenter, randomized, controlled study of 4,071 adults with acute ischemic stroke and hypertension (SBP; 140 to 220 mmHg).
The Carotene and Retinol Efficacy Trial (CARET) was a large, multicenter randomized chemoprevention trial designed to test a combined lung cancer prevention agent in heavy smokers and workers exposed to asbestos.
Our study has some limitations despite being a large multicenter nationwide study.
By far the largest trial has been a large multicenter, randomized, double-blind study of 539 adolescents published in 2005.
PLuSS was also a smaller, single-center study, whereas the NLST was a large, multicenter study with extended follow-up.
GLADAR (Grupo Latino Americano de Estudio de Artritis Reumatoide) was a large, multicenter, multinational inception cohort of Latin American patients.
The Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) Study was a large multicenter multinational blinded study published in 2008 (5).
To our knowledge, there has not been a large multicenter epidemiological study of Chinese MM patients until now.
The OPMS study is a large multicenter, naturalistic, 1-year study in Japan with 1850 participants meeting the inclusion criteria.
