One of these genes directly regulated by PRDM16 known as Pdzrn3, appears to be a key regulator of the ultimate organization of the brain.
Ca2+ may be a key regulator between ERS and heart failure.
G9a may be a key regulator of these changes under neuropathic pain conditions.
The collective evidence suggests that TAN may be a key regulator of inflammation and immune status.
EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C.
Notably, there is also an elevated expression of Kif4A in OSCC and it was speculated to be a key regulator for tumoral progression of human oral cancer16.
The expression level of these enzymes could vary across different cell types and tissues, and be a key regulator for modulating mitochondrial protein synthesis.
OPN is a key regulator of bone biology and appears, based on our studies, to also be a key regulator of adipocyte biology.
In cancer cells, AMPK is reported to be a key regulator of autophagy via a mechanism that involves inactivation of mTOR [30] and cardiac myocytes [31].
mTOR seems to be a key regulator of cell size and protein synthesis combining signals from growth factors and nutrients [9], [11].
So scientists and physicians have suspected that steroid hormones such as estrogen may be a key regulator of autoimmune diseases including SLE [11].
