Sentence examples for be a key pathophysiological from inspiring English sources

Specifically, C9ORF72 repeat expansions decrease the levels of TDP-43 or FUS, which could affect RNA transport or processing and may be a key pathophysiological trigger for FTD-ALS.

Therefore, while it is apparent that South Asians have a higher degree of insulin resistance than do members of other ethnic groups, an early impairment in β-cell function could also be a key pathophysiological mechanism in T2DM development in South Asians.

Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing motor and nonmotor symptoms.

Airway liquid hyper-absorption is a key pathophysiological link between the genetic mutations of cystic fibrosis (CF) and the development of lung disease.

Leukocyte-mediated pulmonary inflammation is a key pathophysiological mechanism involved in acute respiratory distress syndrome (ARDS).

Oxidative stress is a key pathophysiological process responsible for NAFLD [ 26].

Endothelial progenitor cells also demonstrate promise in reducing endothelial damage, which is a key pathophysiological feature of ALI.

Recent compelling data from mouse knockout studies indicate that ADAMTS-5 is a key pathophysiological mediator of aggrecan catabolism in cartilage [ 6, 7].

Others have found that S100A4 is an early marker of fibroblast activity and that these fibroblasts are derived from epithelial cells and are a key pathophysiological step in the development of fibrosis [ 17, 33].

Interest in EPCs stems from the fact that endothelial damage is a key pathophysiological feature of ALI, contributing to hyaline membrane formation and development of protein-rich alveolar edema [ 20].

In a pathophysiological context, LPA might be a key factor in non-alcoholic fatty liver disease (Nagle et al., 2009; Wendel et al., 2009).