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The work has led to the radically new notion--which is far from proven--that prionlike changes in protein shape may be a key molecular event in the formation of stable memories, says neuroscientist Solomon Snyder of Johns Hopkins University in Baltimore, Maryland.
PPARγ has been recently shown to be a key molecular switch in the induction of alternatively activated macrophages [ 50].
If this prediction is true, in addition to be a key molecular component of defensive mechanisms against diet-induced obesity SIRT1 in POMC neurons will also need to be considered as a critical regulator of lifespan.
Unexpectedly, we found that NF- κB transcription activity was not significantly affected by bortezomib, although inhibition of the transcription factor NF- κB by bortezomib was thought to be a key molecular mechanism for antimyeloma.
The loss of genomic stability appears to be a key molecular and pathogenetic step occurring early in tumourigenesis creating a permissive environment for the occurrence of alterations in tumour suppressor genes and oncogenes [ 3].
It is very attractive to envisage that upregulation of IAPs during the caspase-mediated microglia activation is responsible for holding back caspase-3 in terms of activity and subcellular localization and therefore would be a key molecular event in preventing the cell death.
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Collectively, these results support our hypothesis that Ang1 is a key molecular regulator of pathological vascularization characteristic of malignant astrocytomas.
Choi, E. S. et al. Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model.
The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch that is activated by a myriad of cell surface receptors to promote cancer cell migration/invasion and survival.
These results suggest that OsLAP6/OsPKS1 is a key molecular switch of the male fertility in both japonica and indica rice.
Together with these results, we suggest that OsLAP6/OsPKS1 is a key molecular switch of pollen exine formation in rice male reproductive development, and has possible applications in hybrid rice breeding.
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Justyna Jupowicz-Kozak
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