TXNIP has been recently shown to be a key mediator in hyperglycemia-mediated inflammatory response and beta-cell apoptosis (Minn et al. 2005; Zhou et al. 2010).
Other work showed the RAL-GEF effector TANK-binding kinase 1 (toK1) to be a key mediator of RAL activity in NRAS-mutant melanoma, with its siRNA-mediated knockdown found to prevent tumour invasion and migration (Vu and Aplin, 2014).
Leptin has been postulated to be a key mediator linking obesity and hyperuricemia as a potential regulator of SUA level.
KiSS1 is considered to be a key mediator of molecular mechanism of reproduction (puberty and prolificacy) in mammals.
Ongoing inflammation appears to have myocardial effects, and accelerated myocardial fibrosis appears to be a key mediator of HIV-induced DD.
Increase in kidney IGF-I levels due to its increased trapping from the circulation was hypothesized to be a key mediator of compensatory renal enlargement.
Aldosterone, a potent stimulator of myocardial and vascular fibrosis, may be a key mediator of HF progression in this population and is therefore an important therapeutic target.
These authors suggest that interactions between the microtubule binding protein Tau and actin may be a key mediator of Tau-related neurotoxicity [48].
Since activation of JNK on its own produced similar effects to those caused by loss of dVps4, we reasoned that JNK signalling may be a key mediator of the defects observed in dVps4 deficient cells.
This is particularly relevant in the case of a cancer-associated mutation, since Smad3 has been shown to be a key mediator of the TGF-β cytostatic program [33].
Annexin A2 has been shown to be a key mediator in modulation of cell morphology through its interactions with the cytoskeleton and lipid rafts including actin and the caveolins [40] and to be part of a complex with caveolins for cholesteryl ester transport [41].
