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Spindle orientation seems to be a key initial factor in acquisition of asymmetric cell fates.
In this context, cellular actin filaments were shown to be a key initial regulator of cell morphology in response to extracellular mechanical forces [ 30].
The existence of amorphous calcium phosphate complexes and their coaggregation with amorphous calcium oxalate may be a key initial step in the mechanism leading to the formation of calcium oxalate (CaOx) stones.
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Substrate preparation is a key initial step in the production of quality thermal sprayed coatings.
Protein adsorption is a key initial event that transforms the surface of a biomedical device into a biological substrate that will govern subsequent cellular interactions.
Priming T cell generation is a key initial step in T cell-based immune responses against tumor cells and pathogens [18], [25].
The blood brain barrier (BBB) is rich in type IV collagen, a substrate of MMP-9 (gelatinase B), and its breakdown is a key initial step in the pathophysiology of CNS leukocyte influx [8], [9].
Platelet adhesion to collagen is a key initial step in arterial thrombosis.
Phosphorylation is a key initial event in the activation of these Smad proteins.
These findings suggest that telomere shortening is a key initial event in colorectal carcinogenesis.
Autophosphorylation of FAK at Tyr397 is a key initial step in the formation of Src-PTK/FAK complexes, which in turn mediate the phosphorylation of FAK associated proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com