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Taken at face value, these results suggest, but do not prove, that extra-cellular ROS release induced in PMNs by opsonized merozoites, may be a key effector function for protection against blood stage P. falciparum infection, despite the lack of prominence of either PMN or ROS in many reviews on the subject, if they are mentioned at all [20], [21].
The transcription cofactor YAP (Yes-associated protein) might be a key effector of renal regeneration and fibrogenesis.
The results indicated that YAP may be a key effector of the Hippo pathway in AKI regulation.
In this context, VAV3 might be a key effector whose expression is differentially regulated by ERα [ 7].
Surface-bound gal-1 was found to be a key effector of regulation mediated by Treg cells, which is consistent with the non-antigen-specific nature of suppression.
The activity of this mediator in the canonical wnt pathway suggests its differential regulation may be a key effector of altered osteoblast differentiation in the setting of osteoporosis.
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Li, Y. et al. A nematode calreticulin, Rs-CRT, is a key effector in reproduction and pathogenicity of Radopholus similis.
The yes-associated protein (YAP) is a key effector of the mammalian Hippo signaling pathway.
This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.
Liberatore, R. A. & Bieniasz, P. D. Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo.
Collectively, these data suggest that IFN-γ is a key effector molecule of the immune system for TRC dormancy induction and maintenance in vitro.
More suggestions(17)
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Justyna Jupowicz-Kozak
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